Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea
Identifieur interne : 001794 ( Main/Exploration ); précédent : 001793; suivant : 001795Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea
Auteurs : M. Kelly [Canada] ; D. G. Butler [Canada] ; J. R. Hamilton [Canada]Source :
- The Journal of Pediatrics [ 0022-3476 ] ; 1972.
English descriptors
- Teeft :
- Acute phase, Adenosine triphosphatase, Alkaline phosphatase, Cholera, Cholera toxin, Clin, Control piglets, Control pigs, Convalescent phase, Deionized water, Dietary lactose, Distal colon, Electrolyte, Enzyme activity, Epithelial cells, Fecal electrolytes, Flame spectrophotometer, Fresh stool, Gastroenteritis, Gesamte virusforsch, Homogenate, Hours post inoculation, Inoculation, Inorganic phosphate, Intestinal, Intestinal mucosa, Intestine, Jejunum, Large intestine, Light microscopy, Litter mates, Male pigs, Minute centrifugation, Mucosal homogenates, Nitric acid, Normal pigs, Original weight, Phosphatase, Pig, Piglet, Proximal, Proximal jejunum, Research institute, Round cell infiltration, Serum determinations, Serum sodium, Sick children, Sigma chemical, Small intestine, Stool determinations, Total volume, Transmissible, Transmissible gastroenteritis, Transmissible gastroenteritis virus, Week post inoculation, Weeks post inoculation.
Abstract
Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.
Url:
DOI: 10.1016/S0022-3476(72)80003-9
Affiliations:
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Kelly</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Research Institute of theHospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Butler, D G" sort="Butler, D G" uniqKey="Butler D" first="D. G." last="Butler">D. G. 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Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kelly, M" sort="Kelly, M" uniqKey="Kelly M" first="M." last="Kelly">M. Kelly</name></noRegion><name sortKey="Butler, D G" sort="Butler, D G" uniqKey="Butler D" first="D. G." last="Butler">D. G. Butler</name><name sortKey="Butler, D G" sort="Butler, D G" uniqKey="Butler D" first="D. G." last="Butler">D. G. Butler</name><name sortKey="Hamilton, J R" sort="Hamilton, J R" uniqKey="Hamilton J" first="J. R." last="Hamilton">J. R. Hamilton</name><name sortKey="Hamilton, J R" sort="Hamilton, J R" uniqKey="Hamilton J" first="J. R." last="Hamilton">J. R. Hamilton</name><name sortKey="Hamilton, J R" sort="Hamilton, J R" uniqKey="Hamilton J" first="J. R." last="Hamilton">J. R. Hamilton</name><name sortKey="Kelly, M" sort="Kelly, M" uniqKey="Kelly M" first="M." last="Kelly">M. Kelly</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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